siRNA-A Tool in Chemical Biology
siRNA or small interfering RNAs owe their origins to the difficulties the scientific community faced utilizing classical and reverse genetics methods in studying gene expression. Disrupting genes to study their functions is not always optimal; neither is mapping mutations back to their genes easy. The whole process is expensive as well as time-consuming, which is why a lot of effort has been devoted to develop methods to silence gene expression in a sequence specific manner using nucleic acids. They have the potential to be powerful tools in the field of chemical biology to study the chemistry of gene expression in therapeutic targets of bacteria and viruses.
- Designing and synthesizing siRNAs
- Biological uses of the RNAi approach
- siRNA based therapeutics
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