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34th International Conference on Chemical Biology & Radiation Therapy, will be organized around the theme “Voices of Chemical Biology and Radiation Therapy: Charting the Next Decade”

CBRT 2018 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in CBRT 2018

Submit your abstract to any of the mentioned tracks.

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Chemical biology is a scientific discipline spanning the fields of chemistry, biology, and physics. It involves application of chemical techniques, tools, and analysis, and often compounds produced through synthetic chemistry, to the study and manipulation of biological systems. Chemical biologists attempt to use chemical principles to modulate systems to either investigate the underlying biological or create new functions. Research done by chemical biologists is often closely related to that of cell biology than biochemistry. Biochemists study the chemistry of biomolecules and regulation of biochemical pathways within cells and tissues, e.g. cAMP or cGMP, while chemical biologists deal with novel chemical compounds applied to biology.

  • Track 1-1Biological macromolecules and lipid assemblies
  • Track 1-2Chemical and biological synthesis
  • Track 1-3Molecular biology, biochemistry & regulation
  • Track 1-4Molecular selection and evolution
  • Track 1-5Protein design and engineering
  • Track 1-6Magnetic resonance
  • Track 1-7Diffraction and microscopy
  • Track 1-8Electronic and vibrational spectroscopy
  • Track 1-9Proteins as catalysts
  • Track 1-10Structural chemistry
  • Track 1-11Synthetic chemistry
  • Track 1-12Biophysical chemistry

Chemical biology is one field that exists in the overlap between biology and chemistry. It involves using the techniques, tools, and methods of chemistry to the study of biological systems. Biochemists study the chemical side of biological organisms. They study the chemical reactions that happen inside organisms and the molecular make up of compounds found in organisms. On the other hand it involves stimulating biological systems using chemicals. For example, you might add a chemical or a specially designed sample of molecules to a tissue or cell and see what impact it has. The goal is often to figure out more detail about how the interactions work. Chemical biology usually involves smaller molecules than biochemistry, which looks at large molecules like nucleic acids and proteins.

  • Track 2-1In-vitro chemical genetic screening
  • Track 2-2In-vivo chemical genetic screening
  • Track 2-3Small molecules in chemical biology
  • Track 2-4Small molecule target identification

Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability in regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions. Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers, but the recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.

  • Track 3-1Glycosylation of proteins
  • Track 3-2Chemical synthesis and engineering of glycoproteins
  • Track 3-3Chemoenzymatic synthesis
  • Track 3-4Synthetic studies of GPI-Anchored peptides, glycoproteins, and proteins
  • Track 3-5Chemical approaches to image protein glycosylation
  • Track 3-6Targeting glycan’s of HIV envelope glycoproteins for vaccine design
  • Track 3-7Design, synthesis and evaluation of mucin glycopeptide based cancer vaccine
  • Track 3-8Selective chemical glycosylation of therapeutic proteins
  • Track 3-9Epigenetics and epitranscriptomics

The Organic Chemistry and Chemical Biology section is engaged in a variety of research activities that are underpinned by organic synthesis. Research activities cover a broad range of topics from the development of new reaction methodologies and catalysts, target asymmetric synthesis of molecules with profound biological activity, through to peptide, protein and DNA chemistry, radiochemistry and molecule imaging, single molecule detection, mass spectrometry, bionanotechnology, biocatalysis, chemical genetics and directed evolution.

The interface between inorganic chemistry and biology has been a rich one dating back several centuries. In more recent times, this field has been referred to as bioinorganic chemistry. The core of bioinorganic chemistry has focused on the study of metal sites in metalloproteins and metalloenzymes. Synthetic chemistry, an important component of chemical biology, has been used by bioinorganic chemists to make small molecule spectroscopy and functional models of metal sites in proteins. In addition, the use of small molecules to study biology also applies to inorganic complexes. 

  • Track 4-1Carbohydrate and nucleic acid synthesis
  • Track 4-2Porphyrin systems
  • Track 4-3Metal complexes
  • Track 4-4Biosynthesis
  • Track 4-5Molecular devices
  • Track 4-6Isolation and structure determination
  • Track 4-7Molecular recognition
  • Track 4-8Biomimetic chemistry
  • Track 4-9Combinatorial chemistry
  • Track 4-10Dendrimers
  • Track 4-11Self-assembling systems
  • Track 4-12Synthetic methods
  • Track 4-13Asymmetric catalysis
  • Track 4-14Total synthesis
  • Track 4-15Amino acid and peptide synthesis
  • Track 4-16Biomaterials

Mass spectrometry involves the measurement of the mass-to-charge ratio of ions. It has become an essential analytical tool in biological research and can be used to characterize a wide variety of biomolecules such as sugars, proteins, and oligonucleotides.

  • Track 5-1Instrumentation and methods
  • Track 5-2Protein mass spectrometry
  • Track 5-3Metabolomics
  • Track 5-4Proteomics
  • Track 5-5Mass spectrometry to discover natural products
  • Track 5-6Applications of mass spectrometry in synthetic biology
  • Track 5-7Studying enzyme mechanisms using mass spectrometry: Applications

Chemical biology and proteomics strategies have rapidly emerged as cost effective yet powerful preclinical approaches for the discovery and identification of novel drugs and targets. Advances in the development and combination of novel chemical tools, bioorthogonal techniques, disease-relevant phenotypic systems, chemoinformatics, and chemical proteomics now provide robust and high-throughput workflows for interrogating drug-target-phenotype relationships. These efforts are poised to significantly enrich preclinical discovery programs and are illuminating a new paradigm for the development of novel drugs modulating novel targets.

  • Track 6-1Chemical genetic approach: Small molecule probes
  • Track 6-2Applications for activity-based probes in drug discovery
  • Track 6-3Chemical biology of stem cell modulation
  • Track 6-4Chemical biology of histone modifications
  • Track 6-5Chemologics
  • Track 6-6Antibody-Drug conjugates in oncology
  • Track 6-7Drug discovery by DNA-encoded libraries
  • Track 6-8Chemical biology in regenerative medicine
  • Track 6-9Nanotechnology
  • Track 6-10Highthroughput screening

Computational questions in this area address predicting protein structure and folding, visualization of biomolecules and systems, prediction and analysis of interactions of biological molecules with drugs, small molecules and other biological macromolecules, predicting enzyme function from structure, and predicting protein network interactions. Huge improvements in computing hardware technology have enabled rapid advances in computational biology.

  • Track 7-1Molecular modeling computer simulations of biological systems
  • Track 7-2Designed chemical tools with computational chemistry
  • Track 7-3Computational design of protein function
  • Track 7-4Computational enzymology
  • Track 7-5Computational chemistry tools in glycobiology
  • Track 7-6Molecular modeling of nucleic acids
  • Track 7-7Protein structure prediction
  • Track 7-8Computational modeling of molecular recognition processes
  • Track 7-9Membrane transport from computational methodologies
  • Track 7-10Protein folding theory
  • Track 7-11Design of inhibitors, intercalators, agonists, and antagonists
  • Track 7-12Chemical and spectroscopic probes
  • Track 7-13Bioinformatics

The field of chemical biology embraces the use of new chemical techniques and approaches to solve biologic problems. An ever-increasing exchange of ideas between chemists and biologists is improving drug discovery. Other fields are likely to benefit, too.

  • Track 8-1Cryomicroscopy
  • Track 8-2Atomic force microscopy
  • Track 8-3Differential scanning calorimetry in the study of lipid structures
  • Track 8-4Membrane potentials and membrane probes
  • Track 8-5NMR spectroscopy of protein structure and dynamics
  • Track 8-6NMR imaging
  • Track 8-7NMR contrast agents
  • Track 8-8Molecular dynamics
  • Track 8-9Two-dimensional infrared studies of biomolecules
  • Track 8-10Biological applications of single and two photons fluorescence
  • Track 8-11Optical tweezers
  • Track 8-12PET imaging in chemical biology
  • Track 8-13Chemical genetics
  • Track 8-14Protein crystallography
  • Track 8-15X-ray crystallography of proteins and DNA

Ubiquitin is a small regulatory protein found in most tissues of eukaryotic organisms i.e. it occurs ubiquitously. The addition of ubiquitin to a substrate protein is called ubiquitination or less frequently ubiquitylation. Ubiquitination affects proteins in many ways: it can mark them for degradation via the proteasome, alter their cellular location, affect their activity, and promote or prevent protein interactions.

  • Track 9-1Ubiquitin signaling
  • Track 9-2Ribosome biogenesis
  • Track 9-3Response to stress and extracellular modulators
  • Track 9-4Modulation of cell surface receptors, ion channels and the secretory pathway
  • Track 9-5Morphogenesis of neural networks
  • Track 9-6Neural and muscular degeneration
  • Track 9-7Immune response and inflammation
  • Track 9-8Differentiation and development
  • Track 9-9DNA transcription and repair
  • Track 9-10Cell cycle and division
  • Track 9-11Biogenesis of organelles
  • Track 9-12Apoptosis
  • Track 9-13Antigen processing
  • Track 9-14Viral infection

siRNA or small interfering RNAs owe their origins to the difficulties the scientific community faced utilizing classical and reverse genetics methods in studying gene expression. Disrupting genes to study their functions is not always optimal; neither is mapping mutations back to their genes easy. The whole process is expensive as well as time-consuming, which is why a lot of effort has been devoted to develop methods to silence gene expression in a sequence specific manner using nucleic acids. They have the potential to be powerful tools in the field of chemical biology to study the chemistry of gene expression in therapeutic targets of bacteria and viruses.

  • Track 10-1Designing and synthesizing siRNAs
  • Track 10-2Biological uses of the RNAi approach
  • Track 10-3siRNA based therapeutics

Researchers in the Chemical Biology and Pharmacology cluster use the principles of medicinal chemistry to study drugs and drug action, to develop synthetic compounds for exploration as new pharmaceuticals, and to probe and control normal and abnormal biological processes. Expertise includes synthetic chemistry (including combinations and natural product synthesis), structure-guided and computational drug design, toxicology and metabolism, and bioassay development. Research emphasizes the integration of biology and chemistry, ensuring that students in the cluster receive strong training in the interface between both fields and learn to exploit chemical diversity as a means to understand biology and advance human health.

  • Track 11-1Synthetic methods for medicinal chemistry and chemical biology
  • Track 11-2Applications of fluorinated amino acids and peptides
  • Track 11-3Metabolic biochemistry
  • Track 11-4Natural products synthesis
  • Track 11-5Chemical biology of natural products and macromolecules
  • Track 11-6Reactivity of biomolecules
  • Track 11-7Cancer, Inflammation
  • Track 11-8Neurodegenerative diseases, nanomedicine
  • Track 11-9Antiviral agents
  • Track 11-10Antibiotics

Recently, significant advances have been made in live cell imaging owing to the rapid development of selective labeling of proteins in-vivo. Green fluorescent protein (GFP) was the first example of fluorescent reporters genetically introduced to the protein of interest (POI). While GFP and various types of engineered fluorescent proteins (FPs) have been actively used for live cell imaging for many years, the size and the limited windows of fluorescent spectra of GFP and its variants set limits on possible applications. Synthetic fluorescent probes are smaller than fluorescent proteins, often have improved photochemical properties, and offer a larger variety of colors. The chemical recognition-based labeling reaction often suffers from the compromised selectivity of metal-ligand interaction with the cytosolic environment, consequently producing high background signals. The Use of protein-substrate interactions or enzyme-mediated reactions generally show improved specificity, but each method has its limitations. 

  • Track 12-1Small molecular sensors and their applications
  • Track 12-2Tools for structural and computational analysis of enzymes
  • Track 12-3Importance of radioactive labeling
  • Track 12-4Biosensing
  • Track 12-5Stable isotope in mass spectrometry
  • Track 12-6New synthetic methods for labeling
  • Track 12-7Phosphate modified nucleotides
  • Track 12-8Labile amino acid phosphorylation
  • Track 12-9Phosphate modification and labeling to study mRNA caps

Radiation therapy or radiotherapy, often abbreviated RT, RTx, or XRT, is a therapy using ionizing radiation, generally as part of cancer treatment to control or kill malignant cells and normally delivered by a linear accelerator. Radiation therapy may be curative in a number of types of cancer if they are localized to one area of the body. It may also be used as part of adjuvant therapy, to prevent tumor recurrence after surgery to remove a primary malignant tumor (for example, early stages of breast cancer). Radiation therapy is synergistic with chemotherapy, and has been used before, during, and after chemotherapy in susceptible cancers. The subspecialty of oncology concerned with radiotherapy is called radiation oncology.

  • Track 13-1Bone, cartilage and soft tissue sarcomas
  • Track 13-2Pediatric solid tumors
  • Track 13-3Breast cancer
  • Track 13-4Male reproductive and genitourinary tumors
  • Track 13-5Gynecological tumors
  • Track 13-6Digestive system tumors
  • Track 13-7Central nervous system tumors
  • Track 13-8Head and neck cancers
  • Track 13-9Respiratory system tumors
  • Track 13-10Endocrine system tumors
  • Track 13-11Lymphoreticular system tumors
  • Track 13-12Skin cancers and melanoma

At present, radiotherapy is an interdisciplinary field employing an advanced therapeutic and imaging apparatus and computerized therapy planning and simulation systems. This means that both the patient-related aspects (diagnosis, selection, treatment indication, justification, referral, planning, therapy, follow-up) and the control and measurement procedures, forming the technical part of the treatment process, should be subject to regular planning, verification and, most importantly, constant improvement. While as of late, quality assurance in radiotherapy has been believed to play a key role in ensuring safe and effective treatment in the physical and technical context (efficient equipment, in vivo dosimetry, portal imaging), now a more systemic approach to quality is beginning to prevail. This, however, calls for designing, implementing, maintaining and improving formalized quality systems or, in other words, implementing versatile quality management systems to cover all areas of activity (administrative, organizational, physical, technical and clinical) of a health care institution applying ionizing radiation for medical purposes.

  • Track 14-1Quality management and improvement
  • Track 14-2Patient safety and managing error
  • Track 14-3Methods to assure and improve quality
  • Track 14-4People and quality
  • Track 14-5Quality assurance in radiotherapy
  • Track 14-6Quality control: Equipment
  • Track 14-7Quality control: Patient-specific

Radiophysics (also modern writing "Radio Physics") is a branch of physics focused on the theoretical and experimental study of certain kinds of radiation: its emission, propagation, and interaction with matter.

  • Track 15-1Nuclear transformations
  • Track 15-2Production of X-rays
  • Track 15-3Clinical radiation generators
  • Track 15-4Interactions of ionizing radiation
  • Track 15-5Measurement of ionizing radiation
  • Track 15-6Quality of X-ray beams
  • Track 15-7Measurement of absorbed dose
  • Track 15-8Dose distribution and scatter analysis

External beam radiation therapy (EBRT) directs a beam of radiation from outside the body at cancerous tissues inside the body. It is a cancer treatment option that uses doses of radiation to destroy cancerous cells and shrink tumors. Examples of EBRT include 3D conformal radiation therapy, IMRT, IGRT, TomoTherapy and stereotactic radiosurgery.

 

  • Track 16-1Three-dimensional conformal radiation therapy
  • Track 16-2Intensity modulated radiation therapy
  • Track 16-3Proton beam therapy
  • Track 16-4Neutron beam therapy
  • Track 16-5Stereotactic radiation therapy
  • Track 16-6Image-guided radiation therapy

Internal radiation is also called brachytherapy. A radioactive implant is put inside the body in or near the tumor. Internal radiation therapy (brachytherapy) allows a higher dose of radiation in a smaller area than might be possible with external radiation treatment. It uses a radiation source that’s usually sealed in a small holder called an implant. Different types of implants may be called pellets, seeds, ribbons, wires, needles, capsules, balloons, or tubes. 

  • Track 17-1Brachytherapy
  • Track 17-2Radionuclide therapy
  • Track 17-3Selective internal radiation therapy
  • Track 17-4Implants

The standard localized therapies for cancer include external-beam radiation therapy, brachytherapy. There are several novel approaches in development aimed at improving local disease control and survival, and reducing post-treatment complications. In low-to-intermediate-risk patients, new radiation approaches are being explored to include hypofractionated robotic radiation therapy. For high-risk patients, the focus is on multimodality approaches, especially the addition of chemotherapy.

 

  • Track 18-1Systemic radiation therapy
  • Track 18-2Molecular radiotherapy
  • Track 18-3Adaptive radiotherapy
  • Track 18-4Proton therapy
  • Track 18-5Radiosurgery
  • Track 18-6Volumetric modulated arc therapy
  • Track 18-7Hyperbaric oxygen
  • Track 18-8Gene therapy
  • Track 18-9Immunotherapy
  • Track 18-10Chemotherapy
  • Track 18-11Novel targeted therapies
  • Track 18-12Hypofractionated robotic radiotherapy

Many protocol studies are conducted in which patients are assigned to alternative treatment regimens. Typically the dosimetric specifications will define the maximal and minimal target doses and maximal doses to specify critical normal structures, and the success of the study will depend upon the consistency and reliability with which these dose specifications are applied. A dose prescription is prepared that defines upper and lower target doses as well as normal tissue dose tolerance levels for all organs of interest. This technique can be used during treatment planning to prevent protocol violations of pre-defined severity, or for retroactive correlation of local tumor recurrence and treatment-related morbidity with dose levels in the target and normal tissues. 

  • Track 19-1Elective radiotherapy
  • Track 19-2Pre-operative radiotherapy
  • Track 19-3Post-operative radiotherapy
  • Track 19-4Intra-operative radiotherapy
  • Track 19-5Palliative radiotherapy
  • Track 19-6Radiotherapy associated with chemotherapy
  • Track 19-7Radiation oncology

A Radiopharmaceutical is a drug that can be used either for diagnostic or therapeutic purposes. It is composed of a radioisotope bond to an organic molecule. The organic molecule conveys the radioisotope to specific organs, tissues or cells. The radioisotope is selected for its properties.

 

  • Track 20-1Radioisotopes
  • Track 20-2Radiopharmacy
  • Track 20-3Radiopharmacology
  • Track 20-4Nuclear Medicine

Radioactive waste is a waste product containing radioactive decay material. It is usually the product of a nuclear process such as nuclear fission, though industries not directly connected to the nuclear power industry may also produce radioactive waste. The main approaches to managing radioactive waste to date have been segregation and storage of short-lived wastes, near-surface disposal of low and some intermediate level wastes, and deep burial or transmutation for the long-lived, high-level wastes.

  • Track 21-1Low-level radioactive waste
  • Track 21-2High-level radioactive waste
  • Track 21-3Recyclable and non-recyclable radioactive materials
  • Track 21-4Radioactive materials from nuclear power plants

Radiation dosimetry in the fields of health physics and radiation protection is the measurement, calculation and assessment of the ionizing radiation dose absorbed by the human body. This applies both internally, due to ingested or inhaled radioactive substances, or externally due to irradiation by sources of radiation.

  • Track 22-1Measuring radiation dose
  • Track 22-2Medical dosimetry
  • Track 22-3Environmental dosimetry
  • Track 22-4Radiation exposure monitoring

Radiobiology (also known as radiation biology) is a field of clinical and basic medical sciences that involves the study of the action of ionizing radiation on living things, especially health effects of radiation. Ionizing radiation is generally harmful and potentially lethal to living things but can have health benefits in radiation therapy for the treatment of cancer and thyrotoxicosis. Its most common impact is the induction of cancer with a latent period of years or decades after exposure. High doses can cause visually dramatic radiation burns, and/or rapid fatality through acute radiation syndrome. Controlled doses are used for medical imaging and radiotherapy.

  • Track 23-1Radiation chemistry
  • Track 23-2Radiation poisoning
  • Track 23-3Radiation therapy in cancer
  • Track 23-4Bioelectromagnetics
  • Track 23-5Radiogenomics
  • Track 23-6Bioenergetics

About the basic health system and human resource knowledge. This topic will include characteristics of Health Care System, insurance, health care access, reimbursement in radiation therapy, and applicable human resource topics.