Chemical Biology of Glycoproteins

Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability in regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions. Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers, but the recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.

  • Glycosylation of proteins
  • Chemical synthesis and engineering of glycoproteins
  • Chemoenzymatic synthesis
  • Synthetic studies of GPI-Anchored peptides, glycoproteins, and proteins
  • Chemical approaches to image protein glycosylation
  • Targeting glycan’s of HIV envelope glycoproteins for vaccine design
  • Design, synthesis and evaluation of mucin glycopeptide based cancer vaccine
  • Selective chemical glycosylation of therapeutic proteins
  • Epigenetics and epitranscriptomics

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